Israel, Iran launch more barrages as Israel aims to wipe out Tehran's nuclear program

Iran and Israel targeted each other with airstrikes early on Saturday after Israel launched its biggest-ever offensive against its longtime foe in a bid to prevent it from developing a nuclear weapon.

Air raid sirens sounded in Tel Aviv and Jerusalem, the country's two largest cities before dawn, sending residents rushing into shelters.

The military said its air defence systems were operating, seeking to intercept Iranian missiles.

"In the last hour, dozens of missiles have been launched at the state of Israel from Iran, some of which were intercepted," the Israeli military said.

It said rescue teams were operating at a number of locations across the country where fallen projectiles were reported, without commenting on casualties.

Several explosions were heard in the Iranian capital Tehran, the semi-official Tasnim news agency reported.

The Fars news agency said two projectiles hit Tehran's Mehrabad airport, and Iranian media said flames were reported there.

Close to key Iranian leadership sites, the airport hosts an air force base with fighter jets and transport aircraft.

Israeli media said a suspected missile came down in Tel Aviv, and a Reuters witness heard a loud boom in Jerusalem. It was unclear whether Iranian strikes or Israeli defensive measures were behind the activity.

The Fars news agency said Tehran launched a third wave of airstrikes on Saturday after two salvos on Friday night.

Those were in response to Israel's attacks on Iran early on Friday against commanders, nuclear scientists, military targets and nuclear sites.

In central Tel Aviv, a high-rise building was hit during a wave of the missile attacks, damaging the lower third of the structure, which stands in a densely populated urban area. An apartment block in nearby Ramat Gan was destroyed.

Israel's ambulance service said 34 people were injured on Friday night in the Tel Aviv area, most with minor injuries. Police later said one person had died.