The canvas will be offered on November 12 as part of Sotheby's Impressionist & Modern Art evening sale in New York City.
"Charing Cross Bridge" is one of the seminal London canvases Monet created during multiple trips to London that he undertook in the early 1900s.
This seminal series was painted from the vantage point of Monet's room at the Savoy Hotel, which the French artist found particularly advantageous to capture the city's fog.
London's Charing Cross Bridge remains one of Monet's most emblematic subjects, as he revisited it in 37 canvases completed between 1899 and 1905.
Several of them belong in the collections of international institutions, such as the Art Institute of Chicago, Boston's Museum of Fine Arts and the Thyssen-Bornemisza Museum in Madrid.
"Charing Cross Bridge," which is characterised by its evanescent mix of colour, light and shadow, is expected to fetch between $20 million and $30 million at Sotheby's.
This pre-sale high estimate is well below the French Impressionist's auction record of $110.7 million, which was set last May at Sotheby's New York for "Meules."
As Sotheby's pointed out, Monet's paintings of Charing Cross Bridge still in private hand rarely appear at auction.
The one offered for sale at Sotheby's was purchased in 1977 by the late Andrea Klepetar-Fallek and Fred Fallek, hanging over their living room couch for more than 40 years.
Over the years, the couple established a tradition of giving each other a piece of art for each birthday and anniversary, quickly assembling an impressive collection of paintings, drawings and sculptures.
Among them are works by Pierre Bonnard, Edgar Degas, Lyonel Feininger, Jacques Lipchitz, Emil Nolde and more.
Highlights from the collection include Pierre Bonnard's "Femme se déshabillant," estimated between $1.5 million and $2.5 million; Lyonel Feininger's "Hästende Leute (Hurried People)," estimated between $100,000 and $150,000; as well as Emile Nolde's "Rote Dahlien (Red Dahlias)," estimated between $60,000 and $80,000.
The Klepetar-Fallek Collection will be offered across both Sotheby's evening and day sales of Impressionist & Modern Art, which are set respectively on November 12 and 13.
Ahead of the auctions, all pieces from the collection will be on public view at Sotheby's New York galleries from November 1 through 12.